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Modalert (Modafinil/Provigil) is a stimulant-like drug manufactured by Cephalon, and is approved by the FDA for the treatment of narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Modafinil, like other stimulants, increases the release of monoamines but also elevates hypothalamic histamine levels, leading some researchers to consider Modafinil a "wakefulness promoting agent" rather than a classic amphetamine-like stimulant (as evidenced by the difference in c-fos distribution caused by modafinil as compared to amphetamine). Modalert is also indicated, though not approved, in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), depression, cocaine addiction, Parkinson's Disease, schizophrenia, and disease-related fatigue. By law, however, Cephalon is not allowed to market Modalert for conditions other than those officially approved by the FDA. (in the U.S.)
Modalert and its chemical precursor Adrafinil were developed by Lafon Laboratories, a French company acquired by Cephalon in 2001. Modalert is the primary metabolite of adrafinil, and, while their activity is similar, adrafinil requires a higher dose to achieve equipotent effects.
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